Effects of triparanol and 20,25-diazacholesterol in CNS of rat: Morphological and biochemical studies

@article{Suzuki2004EffectsOT,
  title={Effects of triparanol and 20,25-diazacholesterol in CNS of rat: Morphological and biochemical studies},
  author={K. Suzuki and J. C. Zagoren and S. M. Chen},
  journal={Acta Neuropathologica},
  year={2004},
  volume={29},
  pages={141-156}
}
  • K. Suzuki, J. C. Zagoren, +1 author K. Suzuki
  • Published 2004
  • Biology, Medicine
  • Acta Neuropathologica
  • SummaryWistar strain of rats received daily intraperitoneal or oral administration of Triparanol, 250 mg per kg of body weight or 20,25-diazacholesterol either 30 mg or 60 mg per kg of body weight starting at the age of 5 days old. Prominent intracytoplasmic osmiophilic inclusions identical to those found in the rats treated with AY9944 (Suzukiet al., 1973) and degeneration of myelin sheaths and oligodendroglia were seen in the myelinating white matter of rats sacrificed after 3, 6, and 9… CONTINUE READING
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