Effects of triiodothyronine and retinoic acid on glucokinase gene expression in neonatal rat hepatocytes.

@article{Decaux1997EffectsOT,
  title={Effects of triiodothyronine and retinoic acid on glucokinase gene expression in neonatal rat hepatocytes.},
  author={J F Decaux and M C Juanes and Peter Bossard and Jean Girard},
  journal={Molecular and cellular endocrinology},
  year={1997},
  volume={130 1-2},
  pages={61-7}
}
Glucokinase (EC 2.7.1.2) first appears in rat liver two weeks after birth and increases rapidly after weaning on to a high-carbohydrate diet. We investigated the role of triiodothyronine and retinoic acid in the absence of insulin on the first expression of the glucokinase gene in primary cultures of hepatocytes from 10 day-old rats. These two hormones were able to induce a rapid accumulation of liver glucokinase mRNA, secondarily to a stimulation of gene transcription during the first 24 h of… CONTINUE READING