Effects of triiodothyronine (T3) on the potentiation by antidepressants of l-5-hydroxytryptophan-induced head-twitches in mice

@article{Martin1989EffectsOT,
  title={Effects of triiodothyronine (T3) on the potentiation by antidepressants of l-5-hydroxytryptophan-induced head-twitches in mice},
  author={Patrick Martin and Jacques Massol and Philippe Soubrié and Alain Jacques Puech},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1989},
  volume={13},
  pages={735-748}
}
1. Daily injection of T3 during three consecutive days dose-dependently enhanced L-5-HTP (4 mg/kg)-induced head-twitches in mice. 2. Pretreatment with a sub-effective dose of T3 (0.06 mg/kg) markedly enhanced the ability of drugs acting mainly on noradrenergic systems (clenbuterol, desipramine, maprotiline and nomifensine) to increase the response to L-5-HTP. 3. In contrast the potentiating effects of T3 were moderate on drugs with mixed action on serotonergic and noradrenergic systems… Expand
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