Corpus ID: 30341934

Effects of triflusal in patients with prosthetic heart valves.

@article{Domnguez1985EffectsOT,
  title={Effects of triflusal in patients with prosthetic heart valves.},
  author={Mar{\'i}a Jes{\'u}s Dom{\'i}nguez and Marta Vacas and Yolanda S{\'a}ez and I Olabarr{\'i}a and Aila V. Velasco and Jos{\'e} Antonio Iriarte and Javier Forn},
  journal={Clinical therapeutics},
  year={1985},
  volume={7 3},
  pages={
          357-60
        }
}
The biological effects of a new antiplatelet agent, triflusal, were evaluated in patients with cardiac valvular prostheses. Each patient received 900 mg/day of oral triflusal for 30 days. Triflusal significantly inhibited platelet aggregation induced by adenosine diphosphate (1 to 5 mumol) or epinephrine (12.5 mumol), showing a slight effect on bleeding time (basal: 6 +/- 1.7 min; 30 days of treatment: 8.0 +/- 2.7 min). Serum levels of thromboxane B2 were significantly reduced during treatment… Expand
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients
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Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose
TLDR
A rapid absorption of triflusal and an immediate biotransformation into HTB are obtained, which could be explained by the irreversible inhibition of platelet cyclo-oxygenase and the sustained levels of HTB, which also possess anti-aggregant properties. Expand
Pharmacokinetics of triflusal and its main metabolite in rats and dogs
TLDR
A new analytical technique based on HPLC was developed that enabled us to carry out a pharmacokinetic study of the drug triflusal and its metabolite in animals and indicated an important first pass effect. Expand
Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man
TLDR
2-hydroxy-4-trifluoromethylbenzoic acid is the main active metabolite of the platelet anti-aggregant drug triflusal and had high affinity for plasma albumin, which was not saturable after therapeutic doses. Expand
Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers
ObjectiveTriflusal has been shown to exert neuroprotective effects by downregulating molecules considered responsible for the development of Alzheimer’s disease (AD). The aim of this study was toExpand
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