Corpus ID: 7021125

Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of Ark 2 cells

  title={Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of Ark 2 cells},
  author={Yan-nan Yang and Yan Wang and Xingguang Wang and Shu-Juan Jiang}

Figures from this paper


The analysis of histone modifications [ J ]
  • Biochim Biophys Acta
  • 2006
HDAC‐6 interacts with and deacetylates tubulin and microtubules in vivo
The data provide evidence that HDAC‐6 might act as a dual deacetylase for tubulin and histones, and suggest the possibility that acetylated non‐histone proteins might represent novel targets for pharmacological therapy by HDAC inhibitors. Expand
Histone deacetylase inhibitors in cancer therapy : is transcription the primary target ? [ J ]
  • Cancer Cell
  • 2003
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.
The MPT is a common pathway leading to both nec rotic and apoptotic cell death after ischemia/reperfusion, and the balance between ATP depletion after the MPT and ATP generation by glycolysis determines whether the fate of cells will be apoptotic or necrotic death. Expand
Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation
The presented results indicate that MPT can be detected in living neurons using fluorescent Ca2+ indicators, which would allow the study of the physiological role of MPT in cell death. Expand
Histone deacetylases and cancer: causes and therapies
Together, histone acetyltransferases and histone deacetylases determine the acetylation status of histones, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. Expand
Acetylation and chromosomal functions [ J ]
  • Curr Opin Cell Biol
  • 2000
Global histone acetylation and deacetylation in yeast
The data indicate that targeted modification occurs in a background of global acetylated and deacetylation that not only reduces basal transcription, but also allows a rapid return to the initial state of acetylation when targeting is removed. Expand
The language of covalent histone modifications
It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events. Expand
Histone acetylation and transcriptional regulatory mechanisms.
  • K. Struhl
  • Biology, Medicine
  • Genes & development
  • 1998
Understanding of the causal relationship between histone acetylation and gene expression has been enhanced dramatically by the identification of proteins with intrinsic hist one acetylase and deacetylase activity, which led to a major paradigm shift in understanding of chromatin structure and transcription regulation. Expand