Effects of treatment with fluoride on bone mineral density and fracture risk - a meta-analysis

  title={Effects of treatment with fluoride on bone mineral density and fracture risk - a meta-analysis},
  author={P. Vestergaard and N. J{\o}rgensen and P. Schwarz and L. Mosekilde},
  journal={Osteoporosis International},
  • P. Vestergaard, N. Jørgensen, +1 author L. Mosekilde
  • Published 2007
  • Medicine
  • Osteoporosis International
  • SummaryFluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [≤20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1–0.9 for vertebral and OR = 0.5, 95% CI: 0.3–0.8 for non-vertebral fractures.IntroductionFluoride is incorporated into bone mineral and has an anabolic effect. However, the biomechanical competence of the newly… CONTINUE READING
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