Effects of treatment with fluoride on bone mineral density and fracture risk - a meta-analysis

@article{Vestergaard2007EffectsOT,
  title={Effects of treatment with fluoride on bone mineral density and fracture risk - a meta-analysis},
  author={Peter Vestergaard and Niklas Rye J{\o}rgensen and Peter Schwarz and L. Mosekilde},
  journal={Osteoporosis International},
  year={2007},
  volume={19},
  pages={257-268}
}
SummaryFluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [≤20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1–0.9 for vertebral and OR = 0.5, 95% CI: 0.3–0.8 for non-vertebral fractures.IntroductionFluoride is incorporated into bone mineral and has an anabolic effect. However, the biomechanical competence of the newly… 
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References

SHOWING 1-10 OF 55 REFERENCES
Fluoride for the Treatment of Postmenopausal Osteoporotic Fractures: A Meta-Analysis
TLDR
Although fluoride has an ability to increase bone mineral density at the lumbar spine, it does not result in a reduction in vertebral fractures, and increasing the dose of fluoride increases the risk of nonvertebral fractures and gastrointestinal side effects without any effect on the vertebral fracture rate.
Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk – a meta-analysis
TLDR
It is revealed that PTH alone or in combination with antiresorptive drugs would appear to be able to reduce the risk of vertebral and non-vertebral fractures and to increase spine and perhaps hip BMD.
Effect of sodium fluoride on the prevention of corticosteroid-induced osteoporosis
TLDR
It is concluded that in Cs-treated patients without established osteoporosis NaF prevents bone loss in the lumbar spine but does not have a positive effect on the BMD of the hips.
The Effect of Sodium Monofluorophosphate plus Calcium on Vertebral Fracture Rate in Postmenopausal Women with Moderate Osteoporosis
TLDR
Low-dose fluoride (sodium monofluorophosphate [MFP]) plus calcium in a 4-year, randomized, double-blind, controlled clinical trial in postmenopausal women with moderately low bone mineral density (BMD) of the spine found to be useful in patients with mild to moderate osteoporosis.
Fluoride Salts are no Better at Preventing New Vertebral Fractures than Calcium-Vitamin D in Postmenopausal Osteoporosis: The FAVOStudy
TLDR
It is concluded that flouride-Ca-D regimen was no more effective that Ca-D supplements for the prevention of new vertebral fractures in women with postmenopausal osteoporosis.
Fluoride for treating postmenopausal osteoporosis.
TLDR
Although fluoride has an ability to increase BMD at lumbar spine, it does not result in a reduction of vertebral fractures and in increasing the dose of fluoride, one increases the risk of non-vertebral fracture and gastrointestinal side effects without any effect on the vertebral fracture rate.
Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis.
TLDR
It is concluded that fluoride therapy increases cancellous but decreases cortical bone mineral density and increases skeletal fragility, and the fluoride-calcium regimen was not effective treatment for postmenopausal osteoporosis.
Avoidance of Vertebral Fractures in Men with Idiopathic Osteoporosis by a Three Year Therapy with Calcium and Low-Dose Intermittent Monofluorophosphate
TLDR
Early treatment of idiopathic osteoporosis in the male using the fluoride-calcium regimen tested can improve cancellous and cortical bone density, reduce the incidence of vertebral fractures and attenuate back pain.
Fluoride therapy in prevention of rheumatoid arthritis induced bone loss.
TLDR
The results showed that fluoride therapy was well tolerated and increased vertebral bone mass in patients with RA, and sodium fluoride (40 mg/day) in preventing rheumatoid arthritis induced bone loss and osteoporosis.
Treatment of Postmenopausal Osteoporosis with Slow-Release Sodium Fluoride: Final Report of a Randomized Controlled Trial
TLDR
The cyclical, intermittent use of a lower dose of less bioavailable, slow-release sodium fluoride and continuous supplementation with calcium citrate has been shown to maintain serum fluoride concentrations within the narrow therapeutic window and to stimulate the formation of normally mineralized bone with an improved intrinsic quality of cancellous bone.
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