Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.

@article{Barrera2001EffectsOT,
  title={Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.},
  author={P. Barrera and Leo A B Joosten and Alfons A. den Broeder and L B van de Putte and Piet L. C. M. van Riel and Wim B. van den Berg},
  journal={Annals of the rheumatic diseases},
  year={2001},
  volume={60 7},
  pages={660-9}
}
OBJECTIVES To study the short term effects of a single dose of D2E7, a fully human anti-tumour necrosis factor (TNFalpha) monoclonal antibody (mAb), on the local and systemic homeostasis of interleukin 1beta (IL1beta) and TNFalpha in patients with rheumatoid arthritis (RA). METHODS All patients with RA enrolled in a phase I, single dose, placebo controlled study with D2E7 in our centre were studied. Systemic cytokine levels, acute phase reactants, and leucocyte counts were studied at days 0… CONTINUE READING

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[Etanercept: enbrel].

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