Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder

  title={Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder},
  author={Rachel Yehuda and Sarah L. Halligan and Julia A. Golier and Robert A Grossman and Linda M. Bierer},

Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD

Cortisol and post-traumatic stress disorder in adults

Comparison of basal cortisol levels in adults with current PTSD and in people without psychiatric disorder revealed that studies assessing plasma or serum showed significantly lower levels in people with PTSD than in controls not exposed to trauma.

Changes in cortisol and DHEA plasma levels after psychotherapy for PTSD

Enhanced cortisol suppression following administration of low-dose dexamethasone in first-episode psychosis patients

There may be distinct profiles of HPA axis dysfunction in psychosis which should be further explored, and for the first time that a subset of patients experiencing their first episode of psychosis display enhanced cortisol suppression.

Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment

In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor.

Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder




Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder.

The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology.

Enhanced Dexamethasone Suppression of Plasma Cortisol in Adult Women Traumatized by Childhood Sexual Abuse

Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder.

The data support the hypothesis of an enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal axis in PTSD and combat veterans with PTSD suppressed cortisol to a greater extent than did combat veterans without PTSD and normal controls in response to both doses of dexamethasone.

Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: findings and clinical implications.

  • J. Boscarino
  • Psychology, Medicine
    Journal of consulting and clinical psychology
  • 1996
Morning serum cortisol was compared among Vietnam "theater" veterans and Vietnam "era" veterans to test the hypothesis that individuals with posttraumatic stress disorder experience neuroendocrine system alterations, resulting in significantly lower plasma cortisol.

Prospective study of posttraumatic stress disorder and depression following trauma.

Major depression and PTSD are independent sequelae of traumatic events, have similar prognoses, and interact to increase distress and dysfunction and both should be targeted by early treatment interventions and by neurobiological research.

Urinary Free-Cortisol Levels in Posttraumatic Stress Disorder Patients

A possible role of defensive organization as a basis for the low, constricted cortisol levels in PTSD and paranoid schizophrenic patients is suggested and the possible usefulness of hormonal criteria as an adjunct to the clinical diagnosis of PTSD is suggested.

The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis.

The model of attenuated feedback inhibition in PTSD patients shows that they are unusually reactive to stress and represents an alternative model of acute stress reaction to extremely strong stressful stimulus, and correlates to the hypothesis that in chronic stress-related disease, as psoriasis is, exists, by still undefined mechanism, altered HPA axis function.

Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder

A physiological adaptation of the hypothalamic-pituitary- adrenal axis to chronic stress is suggested in posttraumatic stress disorder (PTSD).