Effects of transgenic mixed-haplotype MHC class II molecules A alpha d A beta z on autoimmune disease in New Zealand mice.

@article{Nishimura1996EffectsOT,
  title={Effects of transgenic mixed-haplotype MHC class II molecules A alpha d A beta z on autoimmune disease in New Zealand mice.},
  author={Hiroyuki Nishimura and Sho Ishikawa and Shingo Nozawa and Masanori Awaji and J. K. Saito and Masaaki Abe and Masahiko Tokushima and Masao Kimoto and Shin Akakura and Hiromichi Tsurui and S. Hirose and Toshikazu Shirai},
  journal={International immunology},
  year={1996},
  volume={8 6},
  pages={967-76}
}
The MHC haplotype heterozygosity (H-2d/H-2z) acts as one major predisposing genetic element for autoimmune disease resembling systemic lupus erythematosus (SLE) in the F1 hybrid of NZB (H-2d) and NZW (H-2z) mice. To determine a possible role of mixed-haplotype A molecules, we introduced a transgene A beta z into H-2d/H-2d homozygous (NZB x NZW.H-2d)F1 mice… CONTINUE READING