Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism

@article{Suzuki2009EffectsOT,
  title={Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism},
  author={Atsushi Suzuki and Patrick Ammann and Keiko Nishiwaki-Yasuda and Sahoko Sekiguchi and Shogo Asano and Shizuko Nagao and Ryosuke Kaneko and Masumi Hirabayashi and Yutaka Oiso and Mitsuyasu Itoh and Joseph Caverzasio},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={28},
  pages={139-148}
}
The type III inorganic phosphate (Pi) transporter Pit-1 was previously found to be preferentially expressed in developing long bones. Several studies also described a regulation of its expression in cultured bone cells by osteotropic factors, suggesting a role of this transporter in bone metabolism. In the present study, we investigated the effects of the transgenic overexpression of Pit-1 in Wistar male rats on calcium phosphate and bone metabolism. A threefold increase and doubling of Pi… CONTINUE READING
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