Effects of trans fats on prostacyclin production

  title={Effects of trans fats on prostacyclin production},
  author={Fred A. Kummerow and Mohamedain M. Mahfouz and Qi Zhou and Christopher Masterjohn},
  journal={Scandinavian Cardiovascular Journal},
  pages={377 - 382}
Abstract Objectives. Prostacyclin is a prostanoid derived from arachidonic acid that prevents thrombosis and is thereby expected to protect against heart disease, while trans fats present in partially hydrogenated oils interfere with arachidonic acid metabolism. Therefore, the objective of the present study was to investigate how fats with different proportions of linoleic acid and trans-18:1 affect prostacyclin released by cultured endothelial cells, and to compare these proportions with those… 
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