• DOI:10.1016/S0041-0101(99)00207-X
Corpus ID: 26124043

Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle.

@article{Sauviat2000EffectsOT,
  title={Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle.},
  author={M. Sauviat and F. Meunier and A. Kreger and J. Molg{\'o}},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2000},
  volume={38 7},
  pages={
          945-59
        }
}

M. Sauviat, F. Meunier, +1 author J. Molgó

Published 2000

Biology, Medicine

Toxicon : official journal of the International Society on Toxinology

The effects of trachynilysin (TLY), a protein toxin isolated from stonefish (Synanceia trachynis) venom, were studied on the electrical and mechanical activities of frog atrial fibres. TLY (1 microg/ml) hyperpolarized the membrane, shortened the action potential (AP) duration (APD), exerted a negative inotropic effect and elicited contracture. These effects did not develop in the presence of atropine. TLY shortened the APD of fibres isolated from a frog completely paralyzed with botulinum type… CONTINUE READING

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