Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle.

@article{Sauviat2000EffectsOT,
  title={Effects of trachynilysin, a protein isolated from stonefish (Synanceia trachynis) venom, on frog atrial heart muscle.},
  author={M. Sauviat and F. Meunier and A. Kreger and J. Molg{\'o}},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2000},
  volume={38 7},
  pages={
          945-59
        }
}
  • M. Sauviat, F. Meunier, +1 author J. Molgó
  • Published 2000
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • The effects of trachynilysin (TLY), a protein toxin isolated from stonefish (Synanceia trachynis) venom, were studied on the electrical and mechanical activities of frog atrial fibres. TLY (1 microg/ml) hyperpolarized the membrane, shortened the action potential (AP) duration (APD), exerted a negative inotropic effect and elicited contracture. These effects did not develop in the presence of atropine. TLY shortened the APD of fibres isolated from a frog completely paralyzed with botulinum type… CONTINUE READING
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