Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex.

@article{EcheverryAlzate2014EffectsOT,
  title={Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex.},
  author={V{\'i}ctor Echeverry-Alzate and Elena Gin{\'e} and Kora M B{\"u}hler and Javier Calleja-Conde and Pedro Olmos and Miguel {\'A}ngel Gorriti and Roser Nadal and Fernando Rodr{\'i}guez de Fonseca and Jose Antonio L{\'o}pez-Moreno},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 12},
  pages={3023-36}
}
BACKGROUND AND PURPOSE Recent and ongoing clinical studies have indicated that topiramate (Topamax®) could be effective in treating ethanol or cocaine abuse. However, the effects of topiramate on the co-administration of ethanol and cocaine remain largely unknown. EXPERIMENTAL APPROACH We studied the effects of topiramate, in Wistar rats, on operant ethanol self-administration with the co-administration of cocaine (i.p.). The psychomotor effects of topiramate were examined before ethanol self… CONTINUE READING

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