Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris.

@article{Bernstein1986EffectsOT,
  title={Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris.},
  author={Joel E Bernstein and Lawrence Charles Parish and Marvin Rapaport and Michael Rosenbaum and Henry H Roenigk},
  journal={Journal of the American Academy of Dermatology},
  year={1986},
  volume={15 3},
  pages={504-7}
}
Alterations in the cutaneous vascular system are prominent in psoriasis and may play an important role in the pathogenesis of this disorder. We evaluated the effects of topically applied capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of cutaneous vasodilatation, on moderate and severe psoriasis. Under a double-blind paradigm, forty-four patients with symmetrically distributed psoriatic lesions applied topical capsaicin to one side of their body and identical-appearing… CONTINUE READING