Effects of topically applied 2% epinephrine and 0.1% dipivalyl epinephrine on the adrenergic nerves as revealed by histofluorescence.

Abstract

Commercially available epinephrine (EPI) 2% and dipivalyl epinephrine (DPE) 0.1% ophthalmic solutions were instilled twice daily in the eyes of rats over a 12-week period and compared to placebo-vehicle-treated controls. Fluorescence photomicrographs of stretch preparations from the dilator muscle of the rat irises showed a weaker fluorescence in the eyes treated with EPI and DPE as compared with controls treated with a placebo vehicle. This study provides further evidence that EPI and DPE treatment can result in a chemical sympathectomy as has been described following topical application of 6-hydroxydopamine.

Cite this paper

@article{Flach1992EffectsOT, title={Effects of topically applied 2% epinephrine and 0.1% dipivalyl epinephrine on the adrenergic nerves as revealed by histofluorescence.}, author={Allan Joseph Flach and Marilyn E. Donahue}, journal={Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde}, year={1992}, volume={205 2}, pages={96-9} }