Effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 infection.

  title={Effects of topical ocular application of 1\% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 infection.},
  author={Chloe B Spertus and Hussni O Mohammed and Eric C. Ledbetter},
  journal={American journal of veterinary research},
  volume={77 10},
OBJECTIVE To determine the effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 (CHV-1) infection. ANIMALS 10 specific pathogen-free Beagles. PROCEDURES 12 months prior to the beginning of the randomized, masked, placebo-controlled 30-day trial, latent ocular CHV-1 infection was experimentally induced in each dog by topical ocular inoculation of both eyes with a field strain of CHV-1. Recurrent… 

Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model

Cidofovir warrants further investigation as treatment for BoHV-1 keratoconjunctivitis, with future studies needed to assess in-vivo tolerability and efficacy.

New Paradigms for the Study of Ocular Alphaherpesvirus Infections: Insights into the Use of Non-Traditional Host Model Systems

Both strengths and limitations of the various available model systems to study ocular herpesvirus infection are discussed, with a focus on the use of these non-traditional virus-natural host models.

Topical Ocular Therapeutics in Small Animals

Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1

Evidence of trans-boundary transmission of a novel form of CHV-1 is presented, which highlights the importance of surveillance for this pathogen in domestic dog populations.

Effect of topical ophthalmic application of cidofovir on experimentally induced primary ocular feline herpesvirus-1 infection in cats.

Twice-daily application of 0.5% cidofovir solution in both eyes significantly decreased the amount of viral shedding and the severity of clinical disease in cats with experimentally induced ocular FHV-1 infection.

In Vitro and In Vivo Evaluation of Cidofovir as a Topical Ophthalmic Antiviral for Ocular Canine Herpesvirus-1 Infections in Dogs

Cidofovir displayed similar in vitro antiviral effects against canine herpesvirus-1 in vitro and in dogs with experimentally induced recurrent ocular CHV-1 infection, a host-adapted pathogen animal model of ocular herpes simplex virus-1 (HSV- 1) infection.

Frequency of spontaneous canine herpesvirus-1 reactivation and ocular viral shedding in latently infected dogs and canine herpesvirus-1 reactivation and ocular viral shedding induced by topical administration of cyclosporine and systemic administration of corticosteroids.

Spontaneous CHV-1 reactivation did not occur frequently in latently infected mature dogs, and this was not altered by topical ocular administration of cyclosporine, which may be a factor contributing to the lower frequency of recurrent herpetic ocular disease in dogs relative to other host species and their associated alphaherpesviruses.

Experimental primary ocular canine herpesvirus-1 infection in adult dogs.

Primary ocular infection of adult dogs with CHV-1 was associated with self-limiting conjunctivitis and ocular viral shedding, which was evident in the absence of clinically detectable keratitis or systemic disease.

Comparative antiviral efficacies of cidofovir, trifluridine, and acyclovir in the HSV-1 rabbit keratitis model.

Topical 1% and 0.5% cidofovir both appeared to be significantly more efficacious than topical trifluridine and acyclovir, during a 7-day course, in the treatment of experimental HSV-1 ocular disease in the New Zealand rabbit keratitis model.

Experimental ocular herpesvirus infection in the cat. Sites of virus replication, clinical features and effects of corticosteroid administration.

The results of this study indicate that while epithelial keratitis may occur during primary infection, stromal ker atitis does not, unless immune responsiveness to FHV-1 is concomitantly suppressed.

Trifluridine decreases ocular HSV-1 recovery, but not herpetic lesions after timolol iontophoresis.

It is suggested that topical treatment with trifluridine may reduce recovery of HSV-1 from the tear film, but does not affect the incidence of iontophoretically induced corneal epithelial lesions.

Acute primary canine herpesvirus-1 dendritic ulcerative keratitis in an adult dog.

A report of dendritic ulcerative keratitis in a 4-year old locally immunosuppressed dog suspected to result from acute primary canine herpesvirus-1 (CHV-1) infection supports a central role for alterations in host immune status in the pathogenesis and clinical manifestations of CHV- 1 ocular disease in dogs.

Canine herpesvirus-1 ocular diseases of mature dogs

  • E. Ledbetter
  • Medicine, Biology
    New Zealand veterinary journal
  • 2013
The understanding of CHV-1 pathophysiology and ocular infections in mature dogs has expanded rapidly during the past few years, but much remains to be elucidated.