Effects of topical adenosine analogs and forskolin on rat pial arterioles in vivo.

  title={Effects of topical adenosine analogs and forskolin on rat pial arterioles in vivo.},
  author={Setsuro Ibayashi and A. C. H. Ngai and Joseph R Meno and H. Richard Winn},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={11 1},
We utilized the closed window technique to study the in vivo responses of rat pial arterioles to superfused adenosine agonists. Adenosine and its analogs dilated pial arterioles and exhibited the following order of potency: 5'N-ethylcarboxamide adenosine (NECA) greater than 2-chloroadenosine (2-CADO) greater than adenosine = R-N6-phenylisopropyladenosine (R-PIA) = S-PIA greater than N6-cyclohexyladenosine (CHA). This potency profile suggests that cerebral vasodilation is mediated through the A2… CONTINUE READING


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