Effects of toluene and benzene air mixtures on human lung cells (A549).

@article{Pariselli2009EffectsOT,
  title={Effects of toluene and benzene air mixtures on human lung cells (A549).},
  author={Fabrizio Pariselli and Maria Grazia Sacco and Jessica Ponti and Diana Rembges},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2009},
  volume={61 4},
  pages={381-6}
}
Human epithelial lung cells (A549) were exposed to toluene and benzene in the air as individual compounds and mixtures at concentrations of about 0.25ppmv in a specifically adapted fumigation device. Possible early toxicological effects at cellular level have been determined by lactate dehydrogenase (LDH), glutathione redox status (GSH) and comet assay. An hour of exposure to 0.25ppmv of toluene in the air induced DNA damages which were repaired within 24h after the treatment. No DNA damage was… CONTINUE READING