Effects of tizanidine on morphine physical dependence: Attenuation and intensification

@article{Koyuncuolu1992EffectsOT,
  title={Effects of tizanidine on morphine physical dependence: Attenuation and intensification},
  author={Hikmet Koyuncuoǧlu and Feyza Aricioglu and Yağız {\"U}resin and Yavuz Dizdar and Yildirim Esin},
  journal={Pharmacology Biochemistry and Behavior},
  year={1992},
  volume={42},
  pages={693-698}
}
It has previously been shown that subchronic and acute administration of L-asparaginase and glutaminase inhibitors D-Aspartic acid (D-ASP) and prolyl-leucyl-glycinamide (PLG) intensifies and attenuates morphine (M) physical dependence, respectively, by the inhibition of ASP and glutamic acid (GLU) production, and subsequently their normal releases. Tizanidine (TIZ) has long been known to be an alpha 2-adrenoceptor agonist and inhibitor of ASP and GLU release. Therefore, in this study TIZ has… Expand
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