Effects of tiaprofenic acid and indomethacin on proteoglycans in the degenerating porcine intervertebral disc.

@article{Karppinen1995EffectsOT,
  title={Effects of tiaprofenic acid and indomethacin on proteoglycans in the degenerating porcine intervertebral disc.},
  author={Jaro I. Karppinen and Ritva Inkinen and Eeva Helena K{\"a}{\"a}p{\"a} and Mikko J. Lammi and Markku I. Tammi and Sten H Holm and Heikki Vanharanta},
  journal={Spine},
  year={1995},
  volume={20 10},
  pages={1170-7}
}
STUDY DESIGN Eighteen pigs were stabbed with a scalpel in the anterior part of the anulus fibrosus of a lumbar disc. After surgery, the pigs received either tiaprofenic acid or indomethacin daily, and a third group did not receive any medication. OBJECTIVES Nonsteroidal anti-inflammatory agents are widely used in the treatment of low back patients, but their long-term effects on the matrix molecules in the degenerate disc are unknown. SUMMARY OF BACKGROUND DATA Several in vitro and in vivo… CONTINUE READING