Effects of thyroxine treatment on histology and behavior using the methimazole model of congenital hypothyroidism in the rat.

The timing of thyroxine (T4) replacement treatment in congenital hypothyroidism (CH) has been suggested to be important for optimizing cognitive recovery in humans; however this has not been fully established using modern animal models of CH. Consequently, the current studies investigated the ameliorating effects of postnatal T4 treatment on neuropathology… CONTINUE READING