Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis.

@article{Durham2016EffectsOT,
  title={Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis.},
  author={E. Leighton Durham and Rebecca N Howie and Laurel E Black and Grace Bennfors and Trish E. Parsons and Mohammed E. Elsalanty and Jack C. Yu and Seth M. Weinberg and James J Cray},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2016},
  volume={106 10},
  pages={803-813}
}
BACKGROUND Craniosynostosis, the premature fusion of one or more of the cranial sutures, is estimated to occur in 1:1800 to 2500 births. Genetic murine models of craniosynostosis exist, but often imperfectly model human patients. Case, cohort, and surveillance studies have identified excess thyroid hormone as an agent that can either cause or exacerbate… CONTINUE READING