Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.

@article{Pressacco1995EffectsOT,
  title={Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.},
  author={Josie Pressacco and Biserka Mitrovski and Charles E Erlichman and David Hedley},
  journal={Cancer research},
  year={1995},
  volume={55 7},
  pages={1505-8}
}
The effects of de novo dTMP inhibition by N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2- thenoyl)-L-glutamic acid (D1694) or N6-[4-(morpholinosulfonyl)benz]-N6-diaminobenz[cd]indole glucuronate (AG-331) on clonogenic survival, thymidylate synthase (TS) and thymidine kinase (TK) activity, and expression of S-(p-nitrobenzyl)-6-thioinosine-sensitive nucleoside transporter (NT) sites were addressed in the human bladder cancer cell line, MGH-U1. These two TS inhibitors… CONTINUE READING