Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells

  title={Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells},
  author={Yanwen Peng and Zhenguang Chen and Weihua Yu and Qi-feng Zhou and Lingxin Xu and Frank Fuxiang Mao and Gang Huang and Xiu-ming Zhang and Shu-nong Li and Bruce T. Lahn and Andy Peng Xiang},
  journal={Cell Biology International},
Immune Modulation with Thymosin Alpha 1 Treatment.
Tissue Engineering the Thymus and Secondary Lymphoid Organs
The function of the thymus and secondary lymphoid organs are discussed with reference to tissue development, tissue resident progenitor cells and disease, and strategies utilised for tissue engineering and regeneration are discussed.
Historical review of thymosin α 1 in infectious diseases
Data available on the use of Tα1 in infectious disease as well as a vaccine enhancer will be reviewed to possibly generate new working hypothesis and there are some issues that have not yet been properly addressed.
Thymosin α1 continues to show promise as an enhancer for vaccine response
During the 2009 pandemic outbreak of H1N1 influenza, mouse and ferret studies confirmed that the use of higher doses of Tα1 allowed for fewer injections than those used in the previous clinical studies, and a clinical study with Focetria™ MF59‐adjuvanted monovalent H 1N1 vaccine showed that treatment with T α1 twice provided an earlier and greater response to the vaccine.
Serum thymosin alpha 1 levels in normal and pathological conditions
Evidence is growing that diseases characterized by deregulation of immune and/or inflammatory responses are associated with serum levels of Ta1 significantly lower than those of healthy individuals: to date, B hepatitis, psoriatic arthritis, multiple sclerosis and sepsis.


Lymphostromal interactions in thymic development and function
It is becoming increasingly clear that the generation and maintenance of thymic environments that are capable of supporting efficient T-cell development, requires complex interplay between lymphoid and stromal compartments of the thymus.
Controlling the thymic microenvironment.
T cell development in culture.
Microenvironmental regulation of Notch signalling in T cell development.
Review of thymic hormones in cancer diagnosis and treatment.
Generation of hematopoietic stem/progenitor cells with property of strengthened cell mediated immunity from an embryonic stem cell line
The quantity of CD + 3 T lymphocytes increased in medium containing thymopeptide when ES cells differe ntiated into CD 34 + HSPC, which had the advantage in immune reconstitution.
In vitro generation of T lymphocytes from embryonic stem cell-derived prehematopoietic progenitors.
It is demonstrated that a defined subset of ES cells has the potential to generate T cells in vitro and could contribute to greater understanding of the molecular events of hematopoietic induction and T-cell lineage commitment.
The research and application statue of thymic peptide and its preparation
Thymic peptide extracted from thymus is a group of high active peptides with low molecular weight that can regulate immune functions of organism and has been concerned and widely used in clinic now.