Effects of thromboxane A2 synthesis inhibitor (OKY-046) on total liver ischemia in rats.


BACKGROUND The purpose of this study was to determine the effects of OKY-046, a thromboxane A2 (TxA2) synthesis inhibitor, on the hepatic dysfunction produced in rats by liver cell ischemia and reperfusion injury. METHODS Total warm ischemia of the liver was induced by the Pringle maneuver for a period of 45 minutes. The animals were divided into two… (More)


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