Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics.

@article{Aizawa1998EffectsOT,
  title={Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics.},
  author={Hisamichi Aizawa and Hiroshi Inoue and Hitoshi Nakano and Koichiro Matsumoto and Makoto Yoshida and Satoru Fukuyama and Hiroshi Koto and Nobuyuki Hara},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1998},
  volume={59 3},
  pages={185-90}
}
We examined effects of a thromboxane A2 (TXA2) antagonist seratrodast on airway hyperresponsiveness, exhaled nitric oxide (NO), and eosinophils in induced sputum in 14 asthmatics. Subjects were administered 80 mg of seratrodast once a day for 4 weeks. Respiratory conductance (Grs) was measured by the forced oscillation method and airway responsiveness was evaluated as the inhaled dose of methacholine, which induced 35% decrease in Grs. Subjects breathed into a Teflon bag, and NO concentration… CONTINUE READING