Effects of three penetration enhancers on transcorneal permeation of cyclosporine.

Abstract

PURPOSE To investigate the permeation of cyclosporin A (CsA) through fresh and frozen human corneas in the presence and absence of three penetration enhancers: benzalkonium chloride (BZCl), dimethylsulfoxide (DMSO), and Cremophor-EL. METHODS Human corneas, unsuitable for transplantation, were either freshly used for permeability experiments or snap-frozen… (More)

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