Effects of three diterpenoids on tumour cell proliferation and telomerase activity

@article{Yang2009EffectsOT,
  title={Effects of three diterpenoids on tumour cell proliferation and telomerase activity},
  author={Yunshan Yang and Handong Sun and Yiping Zhou and Shu-yu Ji and Ma Lin Li},
  journal={Natural Product Research},
  year={2009},
  volume={23},
  pages={1007 - 1012}
}
Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour… 
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