Effects of three diterpenoids on tumour cell proliferation and telomerase activity

  title={Effects of three diterpenoids on tumour cell proliferation and telomerase activity},
  author={Yunshan Yang and Handong Sun and Yiping Zhou and Shu-yu Ji and Ma Lin Li},
  journal={Natural Product Research},
  pages={1007 - 1012}
Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour… 
Eriocalyxin B Biological Activity: A Review on Its Mechanism of Action
It is proposed that EriB supplies a novel opportunity for the cure of cancer but supplementary investigations along with preclinical trials are obligatory to effectively figure out its biological and pharmacological applications.
Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway.
Xerophilusin B induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma cells and does not cause toxicity in nude mice.
Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines, indicating its safety in treating ESCC.
Telomerase Inhibitors from Natural Products and Their Anticancer Potential
This review aims to provide a fundamental knowledge for research on telomere, working regulation of telomerase and its various binding proteins to inhibit the telomeres/telomerase complex, and suppression of transcriptional and post-transcriptional levels.
Molecules of natural origin, semi-synthesis and synthesis with anti-inflammatory and anticancer utilities.
The screening and assignment of new active structures is addressed, together with other aspects, namely the improvements, both in availability and in effectiveness of action that can be achieved from new derivatives by synthetic or semi-synthetic strategies.
Biotechnological Exploitation of Actinobacterial Members
In the current chapter, it has been tried to introduce the less dealt group of halophilic and halotolerant actinobacteria, and shed light on their potential to be exploited in various industry sectors.
A practical technique for rapid characterisation of ent-kaurane diterpenoids in Isodon serra (Maxim.) Hara by UHPLC-Q-TOF-MS/MS.
INTRODUCTION The diterpenoids are the most important active constituents that contribute to the pharmacological efficacy of Isodon serra (Maxim.) Hara. Clinical studies have revealed that
Diterpenoids of terrestrial origin.
This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products.


[Regulation of telomerase activity and cell cycle of K562 cells by oridonin].
ORI can effectively inhibit telomerase activity in K562 cells and Arresting cell cycle and decreasing the expression of hTERT and C-myc may be the mechanism of action.
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
The results suggest that oridonin may be a potential antileukemia agent that targets AE oncoprotein at residue D188 with low adverse effect, and may be helpful for the treatment of patients with t(8;21) AML.
The antitumor and antibacterial activity of the Isodon diterpenoids.
It is concluded that the α-methylene-cyclopentanone system must be an important active center for antitumor activity against Ehrlich ascites carcinoma inoculated into mice.
Terpenoids. LIII. Antitumor activity of trichorabdals and related compounds.
Among the three types, enmein-, oridonin-, and trichorabdal-type, of diterpenoids from Rabdosia trichocarpa, the latter showed the highest antitumor activity against Ehrlich ascites carcinoma in mice, attributed to synergistic increase arising from the presence of two active sites in one molecule.
Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells.
The studies suggest that the non-cytotoxic agent nifedipine is able to synergistically enhance the anti-tumour effects of cisplatin on U87-MG and U 87-MG-CR cells lacking a Ca(2+)-dependent endonuclease and subsequently to induce apoptosis via interaction of nifEDipine with an as yet uncharacterised functional site other than a calcium channel on target cells.
Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora.
Three new ent-kaurane diterpenoids laxiflorin E (1), laxiflorin H (6) and laxiflorin I (8) were isolated from the leaves of Isodon eriocalyx var. laxiflora, along with nine known diterpenoids,
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  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
Telomeres play an important role in the immortalization of proliferating cells. The long tandem repeats of 5'-TTAGGG-3' sequences in human telomeres are potential targets for the anticancer drug
Cytotoxic ent-kaurene diterpenoids from three Isodon species.