Effects of three diterpenoids on tumour cell proliferation and telomerase activity

@article{Yang2009EffectsOT,
  title={Effects of three diterpenoids on tumour cell proliferation and telomerase activity},
  author={Yunshan Yang and Handong Sun and Yiping Zhou and Shu-yu Ji and Ma Lin Li},
  journal={Natural Product Research},
  year={2009},
  volume={23},
  pages={1007 - 1012}
}
Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour… 
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14 Citations
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14 Citations

Eriocalyxin B Biological Activity: A Review on Its Mechanism of Action
TLDR
It is proposed that EriB supplies a novel opportunity for the cure of cancer but supplementary investigations along with preclinical trials are obligatory to effectively figure out its biological and pharmacological applications.
Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway.
Xerophilusin B induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma cells and does not cause toxicity in nude mice.
TLDR
Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines, indicating its safety in treating ESCC.
Telomerase Inhibitors from Natural Products and Their Anticancer Potential
TLDR
This review aims to provide a fundamental knowledge for research on telomere, working regulation of telomerase and its various binding proteins to inhibit the telomeres/telomerase complex, and suppression of transcriptional and post-transcriptional levels.
Molecules of natural origin, semi-synthesis and synthesis with anti-inflammatory and anticancer utilities.
TLDR
The screening and assignment of new active structures is addressed, together with other aspects, namely the improvements, both in availability and in effectiveness of action that can be achieved from new derivatives by synthetic or semi-synthetic strategies.
Biotechnological Exploitation of Actinobacterial Members
TLDR
In the current chapter, it has been tried to introduce the less dealt group of halophilic and halotolerant actinobacteria, and shed light on their potential to be exploited in various industry sectors.
A practical technique for rapid characterisation of ent-kaurane diterpenoids in Isodon serra (Maxim.) Hara by UHPLC-Q-TOF-MS/MS.
INTRODUCTION The diterpenoids are the most important active constituents that contribute to the pharmacological efficacy of Isodon serra (Maxim.) Hara. Clinical studies have revealed that…
Pharmacophore based virtual screening for natural product database revealed possible inhibitors for SARS-COV-2 main protease
Preparation of chiral building blocks for the enantioselective total synthesis of ent-kauranoids by the pig liver esterase-catalyzed asymmetric hydrolysis of a dialkyl malonate-type prochiral diester
Diterpenoids of terrestrial origin.
TLDR
This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products.
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