Effects of thiosulfate on cyanide pharmacokinetics in dogs.

  title={Effects of thiosulfate on cyanide pharmacokinetics in dogs.},
  author={Dennis M. Sylvester and W. Hayton and Robyn L Morgan and James L. Way},
  journal={Toxicology and applied pharmacology},
  volume={69 2},
One method to treat cyanide poisoning involves the administration of a combination of sodium thiosulfate and sodium nitrite. Sodium thiosulfate is believed to exert its antidotal effect by serving as a sulfur donor, thereby increasing the rate of rhodanese catalyzed biotransformation of cyanide to thiocyanate. To gain insight into the mechanism of action of thiosulfate on cyanide toxicity, a pharmacokinetic analysis of cyanide distribution and metabolism with and without sodium thiosulfate was… CONTINUE READING
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