Effects of thioperamide on the cholinergic system and the step-through passive avoidance test in mice.

@article{Miyazaki1995EffectsOT,
  title={Effects of thioperamide on the cholinergic system and the step-through passive avoidance test in mice.},
  author={Shuichi Miyazaki and Masahiro Imaizumi and Kenji Onodera},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1995},
  volume={17 10},
  pages={653-8}
}
We investigated the effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit in the step-through passive avoidance test in mice, and on contents of acetylcholine and choline in the brain. In a behavioral study, thioperamide (20 mg/kg) alone slightly ameliorated scopolamine-induced learning deficit, and pretreatment with zolantidine, a histamine H2-receptor antagonist, significantly enhanced the ameliorating effect of thioperamide. This enhanced… CONTINUE READING

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