Effects of thiol compounds on methotrexate uptake by murine lymphocytes from thymus and thymic lymphosarcoma.

@article{SotysiakPawuczuk1992EffectsOT,
  title={Effects of thiol compounds on methotrexate uptake by murine lymphocytes from thymus and thymic lymphosarcoma.},
  author={D. Sołtysiak-Pawłuczuk and A. Naciaźek-Wieniawska and A. Danysz and A. Czarnomska},
  journal={Cancer letters},
  year={1992},
  volume={65 3},
  pages={
          251-7
        }
}
The characteristics of methotrexate (MTX) uptake and the effects of exogenous sulfhydryl compounds (i.e. reduced glutathione and cysteine) on MTX accumulation in thymocytes and thymic lymphosarcoma cells has been studied. Significant differences in the rate and the extent of MTX uptake between normal and neoplastic cells were demonstrated. MTX accumulation was found to be more efficient in thymic lymphosarcoma cells as compared with parental cells. In the cells examined, MTX uptake was not… Expand
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