Effects of thiol compounds on methotrexate uptake by murine lymphocytes from thymus and thymic lymphosarcoma.

@article{SotysiakPawuczuk1992EffectsOT,
  title={Effects of thiol compounds on methotrexate uptake by murine lymphocytes from thymus and thymic lymphosarcoma.},
  author={D. Sołtysiak-Pawłuczuk and A. Naciaźek-Wieniawska and A. Danysz and A. Czarnomska},
  journal={Cancer letters},
  year={1992},
  volume={65 3},
  pages={
          251-7
        }
}
The characteristics of methotrexate (MTX) uptake and the effects of exogenous sulfhydryl compounds (i.e. reduced glutathione and cysteine) on MTX accumulation in thymocytes and thymic lymphosarcoma cells has been studied. Significant differences in the rate and the extent of MTX uptake between normal and neoplastic cells were demonstrated. MTX accumulation was found to be more efficient in thymic lymphosarcoma cells as compared with parental cells. In the cells examined, MTX uptake was not… Expand
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Effect of 5-fluorouracil on methotrexate transport and cytotoxicity in HT29 colon adenocarcinoma cells.
TLDR
The results of this study suggest that the increase in cellular GSH level as a result of 5FU pretreatment may play a role in the enhancement of MTX uptake and the cytotoxicity of both drugs in HT29 cells. Expand
Cellular aspects of folate and antifolate membrane transport.
TLDR
The physiological role of reduced folate carriers and folate receptors in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development. Expand
Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.
TLDR
Novel immunoregulatory contribution of galectins in regulating leukocyte turnover independently of apoptosis is suggested, indicating that galectin's effects are cell specific. Expand

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