Effects of thio-tepa and hydroxyurea on sperm production in Lakeview hamsters.

Abstract

The spermatogenic cell sensitivity in the induction of sperm abnormalities by two antineoplastic agents, thio-TEPA and hydroxyurea in inbred Lakeview hamsters was studied and the results were compared with those of similar investigations with mice. Testis weights, epididymal sperm numbers, and body weights were also monitored up to 12 wk after treatment… (More)

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