Effects of theophylline and enprofylline on diaphragmatic contractility.

  title={Effects of theophylline and enprofylline on diaphragmatic contractility.},
  author={D. Murciano and M. Aubier and N. Viires and H. Mal and R. Pariente},
  journal={Journal of applied physiology},
  volume={63 1},
  • D. Murciano, M. Aubier, +2 authors R. Pariente
  • Published 1987
  • Chemistry, Medicine
  • Journal of applied physiology
  • Experimental data suggest that theophylline (T) enhances diaphragmatic contractility by increasing the influx of calcium at the cell membrane level through an inhibition of adenosine receptors (Aubier et al., J. Appl. Physiol. 54: 460-4, 1983). Enprofylline (E) is a xanthine drug that has poor ability to antagonize physiological actions of adenosine. The aim of this study was to compare the effects on diaphragmatic contractility of T and E in order to determine whether antagonism of adenosine… CONTINUE READING
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