Effects of the volatile anesthetic sevoflurane on tonic GABA currents in the mouse striatum during postnatal development.


The volatile anesthetic sevoflurane, which is widely used in pediatric surgery, has proposed effects on GABAA receptor-mediated extrasynaptic tonic inhibition. In the developing striatum, medium-sized spiny projection neurons have tonic GABA currents, which function in the excitatory/inhibitory balance and maturation of striatal neural circuits. In this… (More)
DOI: 10.1111/ejn.12691


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