Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions.

@article{Sedgwick2005EffectsOT,
  title={Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions.},
  author={Julie B. Sedgwick and Kristyn J Jansen and Jeffrey D. Kennedy and Hirohito Kita and William W. Busse},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 4},
  pages={
          812-9
        }
}
Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: Lack of interaction with nitric oxide
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TLDR
Recent understanding of the role of adhesion molecules in eosinophil recruitment in the inflamed conjunctiva along with effective treatments for allergic conjunctivitis is reviewed.
Recent Developments in Targeting Eosinophil Accumulation as a Novel Therapeutic Approach for Asthma
TLDR
The problems and successes in recent developments in therapeutic strategies aimed at reducing eosinophil-mediated inflammation in the asthmatic lung are summarized.
The effect of a single inhaled dose of a VLA‐4 antagonist on allergen‐induced airway responses and airway inflammation in patients with asthma
TLDR
It is suggested that VLA‐4 may not play a major role in allergen‐induced airway responses and inflammation in asthma.
CD69 Controls the Pathogenesis of Allergic Airway Inflammation1
TLDR
CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients, according to results.
PI3K, ERK, p38 MAPK and integrins regulate CCR3‐mediated secretion of mouse and human eosinophil‐associated RNases
TLDR
The signal transduction that regulates EARs secretion in response to physiological stimuli, such as chemokines, has been little studied in human and scarcely in mouse eosinophils, the foremost animal model for eos inophil‐associated human diseases.
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