Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice

@inproceedings{Batra2012EffectsOT,
  title={Effects of the tropical ginger compound,1’-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice},
  author={Vinita R Batra and Zanobia A Syed and Jennifer N Gill and Malari A Coburn and Patrick A. Adegboyega and John DiGiovanni and James Michael Mathis and Runhua R. Shi and John L. Clifford and Heather E Kleiner-Hancock},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2012}
}
The purpose of the current study was to determine whether a tropical ginger derived compound 1'-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were… CONTINUE READING
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