Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.

@article{Grover2004EffectsOT,
  title={Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine.},
  author={Gary James Grover and Donald M Egan and Paul G. Sleph and Blake C. Beehler and Grazia Chiellini and N N Nguyen and J. D. Baxter and Thomas S. Scanlan},
  journal={Endocrinology},
  year={2004},
  volume={145 4},
  pages={1656-61}
}
Current drug therapies for obesity are ineffective, and existing treatments for lipid disorders can be further improved. Thyroid hormones affect both conditions, although currently available nonselective thyromimetics are not clinically useful for such treatment due to cardiac side effects. Recent studies suggest that thyroid hormone receptor subtype beta (TRbeta) selective agonists have a profile in which cholesterol can be reduced with minimal tachycardia. The purpose of this study was to… CONTINUE READING

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