Effects of the synthetic estrogen ethinylestradiol on early life stages of mink frogs and green frogs in the wild and in situ

  title={Effects of the synthetic estrogen ethinylestradiol on early life stages of mink frogs and green frogs in the wild and in situ},
  author={Brad J. Park and Karen A. Kidd},
  journal={Environmental Toxicology and Chemistry},
  • Brad J. Park, K. Kidd
  • Published 1 August 2005
  • Biology, Environmental Science
  • Environmental Toxicology and Chemistry
Estrogenic contaminants are known to disrupt growth and development in amphibians. Field‐based research is needed to elucidate their potential impacts on wild populations. Hatch success, larval growth and development rates, and gonad development were examined in native amphibians exposed to low ng/L concentrations of 17α‐efhinylestradiol (EE2) in a whole‐lake addition experiment at the Experimental Lakes Area, northwestern Ontario, Canada. Egg masses were reared in situ in the EE2‐amended lake… 
Transcriptional changes in African clawed frogs (Xenopus laevis) exposed to 17α-ethynylestradiol during early development
The hypothesis that sets of genes derived from studies in teleost fish can be extrapolated for use in amphibians during the juvenile stage but not in sexually undifferentiated individuals is supported.
Effects of prochloraz and ethinylestradiol on sexual development in Rana temporaria.
The study shows that ethinylestradiol may induce vitellogenesis and prochloraz may affect the sexual development in Common frogs.
Interspecies differences in biochemical, histopathological, and population responses in four wild fish species exposed to ethynylestradiol added to a whole lake
It appears that VTG induction is not sufficient to predict effects of xenoes- trogens on fish populations, however, stronger predictions can be made when VTGs induction is assessed in conjunction with histopathological evidence of liver, kidney, and gonad tissue damage.
Effects of Ethinylestradiol and the fungicide Prochloraz on metamorphosis and thyroid gland morphology in Rana temporaria
Ethinylestradiol and prochloraz, however not in environmentally relevant doses, may therefore impact the thyroid axis, and may cause other sublethal effects especially in combination with other stressors likely encountered.
Direct and indirect responses of a freshwater food web to a potent synthetic oestrogen
  • K. Kidd, M. Paterson, K. Liber
  • Environmental Science
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2014
The results demonstrate that small-scale studies focusing solely on direct effects are likely to underestimate the true environmental impacts of oestrogens in municipal wastewaters and provide further evidence of the value of whole-ecosystem experiments for understanding indirect effects of EDCs and other aquatic stressors.


Induction of Vitellogenin and Histological Effects in Wild Fathead Minnows from a Lake Experimentally Treated with the Synthetic Estrogen, Ethynylestradiol
Histological examination of tissues from EE2-exposed male fatheads in Lake 260 showed widespread fibrosis and inhibition of testicular development, and enlargement of liver cells, edema in the interstitium between kidney tubules, and eosinophilic deposits in the kidney tubule lumen were also evident in malefatheads from Lake 260.
Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth in larval tiger salamanders, Ambystoma tigrinum.
The results contradict the expected estrogenic actions of DDT and antiandrogenicactions of p,p'-DDE and show that in A. tigrinum, technical-grade DDT had an antiestrogenic action and p, p'-D DE an estrogenic action.
Effects of endocrine-disrupting contaminants on amphibian oogenesis: methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocytes in vitro.
The activity of methoxychlor in this system indicates that xenobiotics may exert endocrine-disrupting effects through interference with progestin-regulated processes and through mechanisms other than receptor antagonism.
Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds
Results indicate that amphibians could be susceptible to altered gonadal differentiation and development when exposed to estrogenic and antiestrogenic compounds in aquatic environments, such as those impacted by agricultural, industrial, and municipal runoff.
Effects of dibutyl phthalate as an environmental endocrine disruptor on gonadal sex differentiation of genetic males of the frog Rana rugosa.
Findings suggest that DBP was about 1,000-fold less potent than E(2), which is an environmentally dangerous hormone that disrupts the pathways of testicular differentiation in genetically male animals.
Effects of low concentrations of forest‐use pesticides on frog embryos and tadpoles
Bullfrog and green frog tadpoles appear to be more sensitive than leopard frog tadPoles, and bullfrog tadpole were consistently more sensitive to green frog Tadpoles, who were initially affected by exposure to lower concentrations of femtrothion or tnclopyr usually recovered within 1 to 3 d.
Effects of estrogenic hormones on early development of Xenopus laevis.
The present results demonstrate that 10(-5) M E2 and DES induced embryo death and malformations and that ER may be involved in the induction of various developmental defects in X. laevis embryos.
Effects of styrene monomer and trimer on gonadal sex differentiation of genetic males of the frog Rana rugosa.
It is suggested that the styrene monomer and trimer induced a weak estrogen-like effect on the pathways of testicular differentiation in genetically male tadpoles.
Toxicity of endosulfan to aquatic stages of anuran amphibians
The results indicate that the aquatic stages of anuran amphibians may be sensitive to levels of the pesticide endosulfan that could reach their habitat by means of direct applications or drift from aerial spraying.