• Medicine, Biology
  • Published in
    Journal of clinical…
    1992

Effects of the streptococcal preparation OK-432 on in vitro cytokine production of peripheral blood mononuclear cells in patients with chronic viral hepatitis.

@article{Yamashiki1992EffectsOT,
  title={Effects of the streptococcal preparation OK-432 on in vitro cytokine production of peripheral blood mononuclear cells in patients with chronic viral hepatitis.},
  author={Masayoshi Yamashiki and Akira Nishimura and Koujiro Takase and T Nakano and Y Kosaka},
  journal={Journal of clinical & laboratory immunology},
  year={1992},
  volume={38 2},
  pages={
          73-82
        }
}
We obtained peripheral blood mononuclear cells from 12 chronic hepatitis Type B patients, 12 Type C patients, and 15 healthy volunteers, and investigated the effects of OK-432, a streptococcal preparation, on in vitro production of 3 types of cytokines. Mononuclear cells in a concentration of 1 x 10(6) cell/ml were prepared in the culture medium. OK-432 (Chugai Pharmaceutical Co., Ltd., Tokyo) was added to this preparation and incubated for one to 4 days. Thereafter interleukin-1 beta (IL-1… CONTINUE READING