Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents.

@article{Helyes2006EffectsOT,
  title={Effects of the somatostatin receptor subtype 4 selective agonist J-2156 on sensory neuropeptide release and inflammatory reactions in rodents.},
  author={Zsuzsanna Helyes and Erika Pint{\'e}r and J{\'o}zsef N{\'e}meth and Katalin S{\'a}ndor and Kriszti{\'a}n Elekes and Arp{\'a}d Szab{\'o} and G{\'a}bor Pozsgai and D{\'a}niel Keszthelyi and L{\'a}szl{\'o} Kereskai and Mia T Engstr{\"o}m and Siegfried Wurster and J{\'a}nos Szolcs{\'a}nyi},
  journal={British journal of pharmacology},
  year={2006},
  volume={149 4},
  pages={405-15}
}
BACKGROUND AND PURPOSE Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably via sst4/sst1 receptors. This study investigates the effects of a high affinity, sst4-selective, synthetic agonist, J-2156, on sensory neuropeptide release in vitro and inflammatory processes in vivo. EXPERIMENTAL APPROACH Electrically-induced SP, CGRP and… CONTINUE READING

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