Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.

@article{Galle1999EffectsOT,
  title={Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.},
  author={Jan Galle and Ulrike Zabel and Ute Huebner and Armin Hatzelmann and Brunhilde Wagner and Chistoph Wanner and Hartmut H-J Schmidt},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 1},
  pages={195-203}
}
The vasomotor and cyclic GMP-elevating activity of YC-1, a novel NO-independent activator of soluble guanylyl cyclase (sGC), was studied in isolated rabbit aortic rings and compared to that of the NO donor compounds sodium nitroprusside (SNP) and NOC 18. Similarly to SNP and NOC 18, YC-1 (0.3-300 microM) caused a concentration-dependent, endothelium-independent relaxation that was greatly reduced by the sGC inhibitor 1-H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ 10 microM; 59% inhibition of… CONTINUE READING