Effects of the silencing of hypoxia-inducible Factor-1 alpha on metastasis of pancreatic cancer.


BACKGROUND Hypoxia plays a crucial role in the development of solid tumors. Hypoxia-inducible factor-1alpha (HIF-1alpha) is essential for this process, and has been suggested to be a target for cancer therapy. New therapeutic approaches for pancreatic cancer are needed owing to the extremely poor prognosis, in large part as a consequence of high rates of… (More)


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