Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.

@article{Kawasaki2009EffectsOT,
  title={Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.},
  author={Brian T. Kawasaki and Elaine M. Hurt and Madhuri Kalathur and Mar{\'i}a Ana Duhagon and John A. Milner and Young Shik Kim and William L. Farrar},
  journal={The Prostate},
  year={2009},
  volume={69 8},
  pages={
          827-37
        }
}
Recent evidence suggests tumor-initating cells (TICs), also called cancer stem cells, are responsible for tumor initiation and progression; therefore, they represent an important cell population for development of future anti-cancer therapies. In this study, we show that the sesquiterpene lactone parthenolide (PTL) is cytotoxic to prostate TICs isolated from prostate cancer cell lines: DU145, PC3, VCAP, and LAPC4, as well as primary prostate TICs. Furthermore, PTL inhibited TIC-driven tumor… CONTINUE READING

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