Effects of the selective delta opioid agonist SNC80 on cocaine‐ and food‐maintained responding in rhesus monkeys

@article{Carmo2006EffectsOT,
  title={Effects of the selective delta opioid agonist SNC80 on cocaine‐ and food‐maintained responding in rhesus monkeys},
  author={Gail Pereira Do Carmo and Nancy K. Mello and Kenner C. Rice and S Stevens Negus},
  journal={The FASEB Journal},
  year={2006},
  volume={20}
}

Effects of the monoamine uptake inhibitors RTI-112 and RTI-113 on cocaine- and food-maintained responding in rhesus monkeys

Selective Suppression of Cocaine- versus Food-Maintained Responding by Monoamine Releasers in Rhesus Monkeys: Benzylpiperazine, (+)Phenmetrazine, and 4-Benzylpiperidine

TLDR
Findings support the potential utility of dopamine-selective releasers as candidate treatments for cocaine dependence and examine the effects of the releasers benzylpiperazine, (+)phenmetrazine, and 4-benzylpipersidine, which have 20- to 48-fold selectivity in vitro for releasing dopamine versus serotonin.

Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats

TLDR
The results confirm and extend earlier findings and indicate that acute administration of aripiprazole can decrease cocaine self-administration and shift the cocaine choice curve to the right as an acute treatment, and suggest that the concurrent choice procedure in rats has predictive validity of efficacy in humans.

Monoamine Releasers with Varying Selectivity for Dopamine/Norepinephrine versus Serotonin Release as Candidate “Agonist” Medications for Cocaine Dependence: Studies in Assays of Cocaine Discrimination and Cocaine Self-Administration in Rhesus Monkeys

TLDR
The results are consistent with the conclusion that dopamine/norepinephrine-selective releasers retain cocaine-like abuse-related effects but may also be capable of producing relatively selective reductions in the reinforcing effects of cocaine.

Upregulation of Nerve Growth Factor in Central Amygdala Increases Sensitivity to Opioid Reward

TLDR
It is reported that morphine that induced reward sensitization, as demonstrated by reinstatement of the behavior of conditioned place preference with sub-threshold priming morphine, epigenetically upregulated the output activity of Ngf encoding the nerve growth factor (NGF) by increasing histone H4 acetylation in the rat central nucleus of the amygdala (CeA).

Endogenous opiates and behavior: 2006

References

SHOWING 1-10 OF 70 REFERENCES

Effects of kappa opioids on cocaine self-administration by rhesus monkeys.

TLDR
It is shown that chronic administration of EKC and U50,588 produce a dose-dependent, kappa receptor-mediated and often sustained decrease in cocaine self-administration, which may complicate their use as treatments for cocaine dependence.

Effects of kappa opioid agonists on cocaine- and food-maintained responding by rhesus monkeys.

  • N. MelloS. Negus
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1998
TLDR
It is suggested that kappa opioid agonists may be a useful approach to the development of new pharmacological treatments for cocaine dependence and undesirable side effects may limit their clinical usefulness.

Effects of μ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of μ-Agonist Efficacy

TLDR
It is suggested that low-efficacy mu-agonists may decrease cocaine self-administration to a greater degree and with fewer undesirable effects than high-efficiency mu-agonist agonists.

Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys

TLDR
These results are consistent with the hypothesis that chronic treatment with d-amphetamine decreases cocaine self-administration in rhesus monkeys, possibly by attenuating the reinforcing effects of cocaine.

Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy.

  • S. NegusN. Mello
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 2002
TLDR
It is suggested that low-efficacy mu-agonists may decrease cocaine self-administration to a greater degree and with fewer undesirable effects than high-efficiency mu-agonist agonists.

Effects of Mixed-Action κ/μ Opioids on Cocaine Self-Administration and Cocaine Discrimination by Rhesus Monkeys

TLDR
Mixed κ/μ agonists appear to offer some advantages over selective κ agonists as potential treatments for cocaine abuse and may reduce cocaine self-administration without altering cocaine's discriminative stimulus effects.

Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys.

TLDR
It is confirmed that 8-CAC acutely decreases cocaine self-administration, and non-selective effects of 8- CAC on food-maintained responding and tolerance to 8-DAC effects on cocaineSelf-Administration may limit its potential for the treatment of cocaine dependence.

Studies of tolerance and dependence with the delta-opioid agonist SNC80 in rhesus monkeys responding under a schedule of food presentation.

TLDR
It is suggested that a pharmacologically selective tolerance develops to delta-agonists after both acute and chronic administration of SNC80 with little or no dependence.
...