Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction.

@article{Eastman1981EffectsOT,
  title={Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction.},
  author={D. Eastman and H. J. Segall},
  journal={Toxicology letters},
  year={1981},
  volume={8 4-5},
  pages={
          217-22
        }
}
  • D. Eastman, H. J. Segall
  • Published 1981
  • Biology, Medicine
  • Toxicology letters
  • The effects of individual pyrrolizidine alkaloids on the mixed-function oxidase (MFO) enzyme aminopyrine N-demethylase were determined in rat liver 10 000 X g supernatant. The pyrrolizidine alkaloids, senecionine, seneciphylline and retrorsine were obtained from Senecio vulgaris. Senecionine and seneciphylline were found to be linear mixed-type inhibitors while retrorsine was found to be a competitive inhibitor of aminopyrine N-demethylase. The average Ki's +/- S.E. for senecionine… CONTINUE READING
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