Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline

@article{Lamas2005EffectsOT,
  title={Effects of the putative dopamine D3 receptor agonist 7-OH-DPAT in rhesus monkeys trained to discriminate cocaine from saline},
  author={X. Lamas and S. S. Negus and N. Mello and M. Nader},
  journal={Psychopharmacology},
  year={2005},
  volume={124},
  pages={306-314}
}
  • X. Lamas, S. S. Negus, +1 author M. Nader
  • Published 2005
  • Psychology, Medicine
  • Psychopharmacology
  • These studies were designed to evaluate the effects of the putative dopamine D3 receptor agonist 7-hydroxy-N,N-di-n-propyl-2-aminotetraline (7-OH-DPAT), alone and in combination with cocaine, in four rhesus monkeys trained to discriminate cocaine (0.4 mg/kg, IM) from saline under a fixed-ratio 30 schedule of food presentation. Under these conditions, cumulative doses of cocaine (0.013–1.3 mg/kg) produced a dose-dependent and complete generalization to the training dose of cocaine in all monkeys… CONTINUE READING
    22 Citations

    Figures, Tables, and Topics from this paper.

    Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
    • 158
    Cocaine self-administration in dopamine D₃ receptor knockout mice.
    • 29
    The dopamine D3 receptor and drug addiction
    • 43

    References

    SHOWING 1-10 OF 53 REFERENCES
    Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats.
    • 52
    Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine
    • 102
    Role of delta opioid receptors in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
    • 46
    Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.
    • 146
    • Highly Influential
    Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.
    • 175
    Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys.
    • 182
    Antagonism of cocaine self‐administration by selective dopamine D1 and D2 antagonists
    • 200
    Pharmacological characterization of the novel discriminative stimulus effects of a low dose of cocaine.
    • 100
    Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys
    • 26