Effects of the pure antiandrogen RU 23.903 (anandron) on sexuality, aggression, and mood in male-to-female transsexuals

  title={Effects of the pure antiandrogen RU 23.903 (anandron) on sexuality, aggression, and mood in male-to-female transsexuals},
  author={Johannes F. L. M. van Kemenade and Peggy T Cohen-Kettenis and Leo Cohen and Louis J Gooren},
  journal={Archives of Sexual Behavior},
Sexuality, aggression, and mood were investigated in 14 presurgical male-to-female transsexuals, undergoing antiandrogenic treatment with anandron, a pure antiandrogen. Subjects were given a test battery the morning prior to treatment onset and after 8 weeks of treatment. In addition they were requested to complete daily forms concerned with sexual behavior and mood. Morning erections and the frequency of thoughts and fantasies about sex decreased after anandron intake. Aggressive feelings were… 
13 Citations

The Effects of Cyproterone Acetate on Sleeping and Waking Penile Erections in Pedophiles: Possible Implications for Treatment*

During the administration of CPA, NPT, laboratory arousal and hormone measures (except prolactin) all decreased and waking laboratory measures were influenced less and were more variable (one subject showed greater arousal than NPT measures).

A Double-Blind Placebo Controlled Trial of Medroxyprogesterone Acetate and Cyproterone Acetate with Seven Pedophiles

The experience suggests that only a minority of pedophiles are likely to accept libido-reducing drugs, and the drugs, which performed equivalently, reduced sexual thoughts and fantasies, the frequency of early morning erections on awakening, thefrequency and pleasure of masturbation, and level of sexual frustration.

The effect of cross-sex hormones on the quality of life, depression and anxiety of transgender individuals: a quantitative systematic review.

Transgender participants who were prescribed cross-sex hormones had statistically significant scores demonstrating improvement on the validated scales that measured quality of life, anxiety and depression when compared to transgender people who had enrolled in a sex-reassignment clinic but had not yet begun taking cross- sex hormones.

What has sex got to do with it? The role of hormones in the transgender brain

Research in this area has the potential to inform the understanding of the developmental origins of gender identity and sex difference in response to gonadal steroid manipulations, but care is needed in research questions and methods to not further stigmatize sex and gender minorities.

Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure

The findings suggest that, throughout life, gonadal hormones remain essential for maintaining aspects of sex-specific differences in the human brain.

Aggression in humans: What is its biological foundation?

Hormonal therapy and sex reassignment: a systematic review and meta‐analysis of quality of life and psychosocial outcomes

The prognosis of individuals with gender identity disorder (GID) receiving hormonal therapy as a part of sex reassignment in terms of quality of life and other self‐reported psychosocial outcomes is assessed.

Transgender Health Concerns

Transgender persons are those who live full-time or part-time in the gender role of the opposite biologic sex (Lawrence et al., 1996). Transgender persons share the same health concerns as



Effects of androgen on sexual behavior in hypogonadal men.

It is concluded that the stimulatory effects of testosterone on sexual activity are rapid, reliable, and not due to a placebo effect and to maintain plasma testosterone and adequate sexual function within normal levels, even high doses of testosterone enanthate should be given no less frequency than once every 3 weeks.

Mood, Sexuality, Hormones, and the Menstrual Cycle. III. Sexuality and the Role of Androgens

&NA; Sexual interest and activity at different stages of the menstrual cycle was recorded by 55 women with normal ovulatory cycles. In women with marked cyclical mood change, there was an associated


Sexual interest increased within the first week of T.U. administration, ejaculation usually returning within the second week, and behaviour responses were similar in the hyper‐ and hypogonadotrophic groups.

Hormones and human sexual behavior.

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The role of sex hormones in the sexuality of men is now becoming clearer and androgens may be beneficial in treating loss of sexual appetite in men but are unlikely to improve erectile dysfunction unless it is secondary to lost sexual appetite.

Sex steroids and pulsatile luteinizing hormone release in men. Studies in estrogen-treated agonadal subjects and eugonadal subjects treated with a novel nonsteroidal antiandrogen.

The role of androgens was studied in 15 eugonadal male subjects by determining the effects of a novel nonsteroidal androgen receptor blocker, Anandron, on basal and LH-releasing hormone (LHRH)-stimulated serum LH/FSH levels; LH pulse frequency and amplitude; sex steroid and sex hormone-binding globulin levels; and serum PRL levels during an 8-week period.

An investigation of the correlation between hormonal levels in males and mood, behavior and physical discomfort

Androgens and aggression in man: A controlled case study

A controlled case study is reported of the behavioural effects of androgen treatment in an institutionalised hypogonadal mentally retarded male patient, and possible reasons for the differential behavioural response to the two androgen preparations are presented.

Postnatal gonadal steroid effects on human behavior.

The characteristically different circulating concentrations of male and female steroid hormones in men and women appear to be partial determinants of certain sexually dimorphic behaviors, interacting in a complex way with psychological and sociocultural factors as well as with other biological factors.

From art to science. The diagnosis and treatment of depression.

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    Archives of general psychiatry
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My own work on the formulation of an operational definition of depression as a disorder, its application into a rating instrument, the various validity and reliability studies performed, as well as clinical application of the rating scale are summarized.