Effects of the pro-inflammatory milieu on the dedifferentiation of cultured fibroblast-like synoviocytes

Abstract

The aim of this study was to determine whether the inflammatory milieu and/or hypoxia induces the dedifferentiation of synovial cells into mesenchymal stem-like cells, which may contribute to the tumor-like growth of synovial cells. Expression of mesenchymal stem cell markers (CD24, CD44, CD90, CD106, CD146 and Stro-1) was compared among cultured fibroblast… (More)
DOI: 10.3892/mmr.2012.767

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