Effects of the potassium channel activator, BRL 34915, on the action potential characteristics of canine cardiac Purkinje fibers.


The effects of various concentrations (1-100 microM) of BRL 34915 on the action potential characteristics were investigated in normal canine Purkinje fibers and Purkinje fibers surviving infarction. For comparison, the electrophysiological effects of BRL 34915 were also examined in normal Purkinje fibers in which the potassium conductance had been reduced… (More)


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