Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release.

@article{Lee2016EffectsOT,
  title={Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release.},
  author={Soah Lee and Xinming Tong and Fan Yang},
  journal={Biomaterials science},
  year={2016},
  volume={4 3},
  pages={405-11}
}
Poly(ethylene glycol) (PEG) hydrogels are widely used to deliver therapeutic biomolecules, due to high hydrophilicity, tunable physicochemical properties, and anti-fouling properties. Although different hydrogel crosslinking mechanisms are known to result in distinct network structures, it is still unknown how these various mechanisms influence biomolecule release. Here we compared the effects of chain-growth and step-growth polymerization for hydrogel crosslinking on the efficiency of protein… CONTINUE READING